The two apps keeping me from running Linux full time are Ableton Live and Adobe Fireworks. Unfortunately it doesn't seem likely that the high-end proprietary content creation tools or anything comparable from the OSS world are likely to come to Linux any time soon.
Never used Ableton, but I've been dabbling in Reaper[0]. I can't make a full switch yet, but am hoping to be able to at some point in time. From the little I've seen it isn't missing anything major.
Final Cut Pro is another story, but I really don't use it very often anymore, and I'm well-versed enough in Adobe Premier that I could probably drop it.
I'm not holding my breath either, but I do dream of a world where most software is OS-independent. I guess we're closer now than we have been for a while.
EDIT: I just remembered that Reaper is Win/Mac. I hear it runs under Wine, but I'd be worried about latency there. Alas, we are captive to our tools.
